学术讲座Nanobiotechnology: applications in liquid biopsy analysis towards cancer diagnosis and treatment response
时间：2024年4月10日下午14:30
地点：理工楼18号楼2-22科研研讨室
主讲：Yuling Wang, Professor, Macquarie University, Australia
主办：光电与信息工程学院，医学光电科学与技术教育部重点实验室，福建省光子技术重点实验室
专家简介：
Professor Yuling Wang is an Australian Research Council (ARC) Future Fellow and a member of ARC College of Experts (2022-2024) in the School of Natural Sciences at Macquarie University, Sydney, Australia. Yuling completed her PhD at Changchun Institute for Applied Chemistry, the Chinese Academy of Sciences in 2009. She was then awarded an Alexander von Humboldt (AvH) fellowship (2010) and a German Research Foundation (DFG) Fellowship (2012). In 2014, she received the ARC Discovery Early Career Researcher Award (DECRA) fellowship and worked at the University of Queensland. She currently leads a group with 5 postdoctoral research fellows, 1 Research Associate, 10 PhD and 2 Master by research students. She is also a Chief Investigator in the ACRF Centre for Advanced Cancer Modelling and Experimental Oncology (COMET). Her research focuses on platform technologies that use rationally designed nanomaterials and advanced spectroscopic tools for biomarker sensing and cancer molecular profiling, with the aim to enhance in vitro diagnostics and personalized medicine.
讲座简介：
Liquid biopsy, referring to the detection of tumor-derived biomolecules in the circulation, has garnered significant attention due to their capability of providing a snapshot of the molecular landscape of cancer for individualized disease management. Therefore, non-invasive analysis of circulating biomarkers has the benefit of rapid and little inconvenience to the patients. However, the translation of liquid biopsy to the clinical applications is still challenging due to the rare amount of cancer-relevant circulating biomolecules against an abundant background of non-target biomolecules. To overcome this technical hurdle, we have proposed a new nanotechnology by utilizing plasmoinc nanomaterial and surface-enhanced Raman scattering (SERS) as the new analytical tools for liquid biopsy analysis towards cancer diagnosis and treatment response.
In this talk, I will present our recent results in this evolving field—from the synthesis of cutting edge plasmonic nanomaterials to the design of biosensor platform, and clinical evaluation of the new nanobiotechnology for liquid biopsy analysis with the focus on the detection of circulating tumour cells (CTCs) and extracellular vesicles (EVs). By taking the advantages of the sensor platforms (e.g. microfluidic device) in fast sample preparation and the unique properties of plasmonic nanomaterials, we target simultaneously and selectively detecting and monitoring of the phenotypes and glycan profiles of CTCs and EVs in response to drug treatment.
