个人简历
北京大学物理学学士，美国宾夕法尼亚大学生物工程博士, 曾任美国麻省理工学院博士后，美国马里兰大学生物工程系助理教授，副教授，美国马萨诸塞大学生物医学工程系副教授，教授。2023 年11月入职福建师范大学光电与信息工程学院，任教授，博士研究生导师。发表110 多篇论文，出版著作1部，发明专利3项，主持和参与多项科研项目。获得美国马里兰大学系教学优秀奖和美国国家科学基金委 (NSF)职业奖。曾任 IEEE Transactions in Biomedical Engineering 的副主编，Scientific Reports 的编委，和美国激光手术与医学协会会士 (Fellow)，美国光学学会资深会员。
Email: yuchen@fjnu.edu.cn
研究方向
生物医学光学成像，包括光学相干断层扫描（OCT）和荧光层析成像（FLOT）等，以及应用于生物医学领域包括癌症检测、移植器官评估、脑功能成像和组织工程等。
研究内容及其它信息参见：http://blog.umd.edu/biophotonics/research/
代表性论文
Q. Tang, T. Nagaya, Y. Liu, J. Lin, K. Sato, H. Kobayashi*, Y. Chen*, “Real-time monitoring of microdistribution of antibody-photon-absorber conjugates during photoimmunotherapy in vivo.” Journal of Controlled Release, 260, 154-163 (2017). 封面文章 （SCI 一区 TOP）
B. Wang, H.W. Wang, H. Guo, E. Anderson, R. Falola, T. Smith, Q. Tang, T. Wu, P.M. Andrews, Y. Chen*, “Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease.” Journal of Biomedical Optics, 22, 121706 (2017).
H. Guo, H.W. Wang, E. Anderson, R. Falola, T. Smith, Q. Tang, M. Levi, P.M. Andrews, Y. Chen*, “Intravital Imaging of Adriamycin-Induced Glomerular Pathology using Two-photon Microscopy and Optical Coherence Tomography.” Journal of Innovative Optical Health Sciences, 11, 1850030 (2018).
S. Wu, Y. Huang, Q. Tang, Z. Li, H. Horng, H. Wu, J. Li, Y. Chen*, H. Li*, “Quantitative evaluation of redox ratio andcollagen characteristics during breast cancerchemotherapy using two-photon intrinsicimaging.” Biomedical Optics Express, 9, 1375-1388 (2018).
Q. Tang, T. Nagaya, Y. Liu, H. Horng, J. Lin, K. Sato, H. Kobayashi*, Y. Chen*, “3D Mesoscopic Fluorescence Tomography for Imaging Micro-distribution of Antibody-photon Absorber Conjugates during Photoimmunotherapy in vivo.” Journal of Controlled Release, 279, 171-180 (2018). 封面文章 （SCI 一区 TOP）
Q. Tang, C. Piard, J. Lin, K. Nan, J. Caccamese, J.P. Fisher*, Y. Chen*, “Imaging stem cell distribution, growth, migration, and differentiation in 3-D scaffolds for bone tissue engineering using mesoscopic fluorescence tomography.” Biotechnology and Bioengineering, 115, 257–265 (2018).
B. Konkel, C. Lavin, T. Wu, E. Anderson, A. Iwamoto, H. Rashid, B. Gaitan, J. Boone, M. Cooper, P. Abrams, A. Gilbert, Q. Tang, M. Levi, J.G. Fujimoto, P.M. Andrews, Y. Chen*, “Fully automated analysis of OCT imaging of human kidneys for prediction of post-transplant function,” Biomedical Optics Express, 10, 1794-1821 (2019). 该工作被英国Institute of Physics 网站专门报导https://physicsworld.com/a/oct-could-help-expand-the-kidney-donor-pool/
S. Wu, H. Guo, H. Horng, Y. Liu, H. Li, P. Daneshpajouhnejad, A. Rosenberg, C. Albanese, S. Ranjit, P.M. Andrews, M. Levi, Q. Tang*, Y. Chen*, “Morphological and functional characteristics of aging kidneys based on two-photon microscopy in vivo,” Journal of Biophotonics, 13, e201900246(2019).
Q. Tang*,V. Tsytsarev,F. Yan, R.S. Erzurumlu*, Y. Chen*, “In vivo voltage-sensitive dye imaging of mouse cortical activity with mesoscopic optical tomography,” Neurophotonics, 7: 041402 (2020).
X. Qin, B. Wang, D. Boegner, B. Gaitan, Y. Zheng, X. Du, Y. Chen*, “Indoor Localization OCT Hand-held Probe using Visual Odometry and Real-time Segmentation using Deep Learning,” IEEE Transactions on Biomedical Engineering, 69:1378-1385 (2022).
M. Moradi, X. Du, T. Huan, Y. Chen*, “Feasibility of the soft attention-based models for automatic segmentation of OCT kidney images,” Biomedical Optics Express, 13:2728-2738(2022).
B. Gaitan, C. Inglut, U. Kanniyappan, H.N. Xu, E.F. Conant, L. Frankle, L.Z. Li, Y. Chen*, H.C. Huang*, “Development of an endoscopic auto-fluorescent sensing device to aid in the detection of breast cancer and inform photodynamic therapy,” Metabolites, 12:1097 (2022).
代表性科研项目
美国 NSF CBET-1254743 “CAREER: Multi-scale Imaging of Neural Interconnects using MRI-compatible Parallel Photonic Needle Interface”02/18/2013 - 02/28/2019；$480,000；主持
美国 NIH R01 DK094877 “Non-Invasive Evaluation of Transplant Kidney using OCT”04/01/2014 - 03/31/2019 ；$1,686,327；参与子课题$528,960
美国 NIH R03 CA176027 “Monitoring Photo-immunotherapy using Multi-channel Multi-modal Imaging Needles” 10/01/2014 - 9/30/2017；$152,000 ；主持
美国 NIH R01 CA 191207 “Redox Imaging for Breast Cancer Prognosis”07/02/2015 - 6/30/2021；$3,313,520；参与子课题$297,018
美国 NIH R01EB014946 “Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds”05/10/2015 - 2/29/2020；$1,288,000；主持
美国NIH R01 DK133717 “Automatic Wide-Field Optical Coherence Tomography for Assessment of Transplant Kidney Viability” 09/16/2022 - 06/30/2026；$2,527,424；共同主持（注：由于回国工作，2023/11 之后移交他人主持）
美国NSFCBET-2229356“Pulse Oximetry Measurement Errors Correlated with Patient Skin Pigmentation: Optical Mechanisms and Effect Multipliers”01/01/2023 - 12/31/2024；$200,000；主持（注：由于回国工作，2023/11 之后移交他人主持）
