陈郁
教授，博士生导师
E-mail：yuchen@fjnu.edu.cn
个人简介
北京大学物理学学士，美国宾夕法尼亚大学生物工程博士, 曾任美国麻省理工学院博士后，美国马里兰大学生物工程系助理教授，副教授，美国马萨诸塞大学生物医学工程系副教授，教授。现任福建师范大学光电与信息工程学院教授，博士研究生导师，医学光电科学与技术教育部重点实验室常务副主任。福建省引进高层次人才。发表110 余篇论文，出版著作1部，发明专利3项，主持和参与多项科研项目。获得美国马里兰大学系教学优秀奖和美国国家科学基金委 (NSF)职业奖（CAREER Award）。任 Biomedical Optics Express 和 《光学学报》编委，美国激光手术与医学协会会士 (Fellow)，美国光学学会资深会员，中国光学学会生物医学光子学专业委员会副主任委员。
课题组招收相关专业的硕士研究生、博士研究生以及博士后研究员。
研究方向
生物医学光学成像，包括光学相干断层扫描（OCT）和荧光层析成像（FLOT）等，以及应用于生物医学领域包括癌症检测、移植器官评估、脑功能成像和组织工程等。
研究内容及其它信息参见：http://blog.umd.edu/biophotonics/research/
代表性论文
1.Q. Tang, T. Nagaya, Y. Liu, J. Lin, K. Sato, H. Kobayashi*,Y. Chen*, “Real-time monitoring of microdistribution of antibody-photon-absorber conjugates during photoimmunotherapy in vivo.” Journal of Controlled Release, 260, 154-163 (2017).封面文章 （SCI 一区 TOP）
2.Q. Tang, T. Nagaya, Y. Liu, H. Horng, J. Lin, K. Sato, H. Kobayashi*,Y. Chen*, “3D Mesoscopic Fluorescence Tomography for Imaging Micro-distribution of Antibody-photon Absorber Conjugates during Photoimmunotherapy in vivo.” Journal of Controlled Release, 279, 171-180 (2018).封面文章 （SCI 一区 TOP）
3.Q. Tang, C. Piard, J. Lin, K. Nan, J. Caccamese, J.P. Fisher*,Y. Chen*, “Imaging stem cell distribution, growth, migration, and differentiation in 3-D scaffolds for bone tissue engineering using mesoscopic fluorescence tomography.” Biotechnology and Bioengineering, 115, 257–265 (2018).
4.B. Konkel, C. Lavin, T. Wu, E. Anderson, A. Iwamoto, H. Rashid, B. Gaitan, J. Boone, M. Cooper, P. Abrams, A. Gilbert, Q. Tang, M. Levi, J.G. Fujimoto, P.M. Andrews,Y. Chen*, “Fully automated analysis of OCT imaging of human kidneys for prediction of post-transplant function,” Biomedical Optics Express, 10, 1794-1821 (2019).该工作被英国Institute of Physics 网站专门报导 https://physicsworld.com/a/oct-could-help-expand-the-kidney-donor-pool/
5.S. Wu, H. Guo, H. Horng, Y. Liu, H. Li, P. Daneshpajouhnejad, A. Rosenberg, C. Albanese, S. Ranjit, P.M. Andrews, M. Levi, Q. Tang*,Y. Chen*, “Morphological and functional characteristics of aging kidneys based on two-photon microscopy in vivo,” Journal of Biophotonics, 13, e201900246(2019).
6.Q. Tang*,V. Tsytsarev,F. Yan, R.S. Erzurumlu*,Y. Chen*, “In vivo voltage-sensitive dye imaging of mouse cortical activity with mesoscopic optical tomography,” Neurophotonics, 7: 041402 (2020).
7.X. Qin, B. Wang, D. Boegner, B. Gaitan, Y. Zheng, X. Du,Y. Chen*,“Indoor Localization OCT Hand-held Probe using Visual Odometry and Real-time Segmentation using Deep Learning,” IEEE Transactions on Biomedical Engineering, 69:1378-1385 (2022).
8.M. Moradi, X. Du, T. Huan,Y. Chen*, “Feasibility of the soft attention-based models for automatic segmentation of OCT kidney images,” Biomedical Optics Express, 13:2728-2738(2022).
9.B. Gaitan, C. Inglut, U. Kanniyappan, H.N. Xu, E.F. Conant, L. Frankle, L.Z. Li,Y. Chen*, H.C. Huang*, “Development of an endoscopic auto-fluorescent sensing device to aid in the detection of breast cancer and inform photodynamic therapy,” Metabolites, 12:1097 (2022).
10.M.Moradi, Y.Chen*, X.Du*, J.Seddon*, “Deep ensemble learning for automated non-advanced AMD classification using optimized retinal layer segmentation and SD-OCT scans,” Computers in Biology and Medicine, 154: 106512 (2023).
11.M.Moradi, Y.Chen*, “Monte Carlo Simulation of Diffuse Optical Spectroscopy for 3D Modeling of Dental Tissues,” Sensors, 23: 5118 (2023).
12.X. Ma, M. Moradi, X. Ma,Q. Tang, M. Levi, Y. Chen*, H. K. Zhang*, “Large area kidney imaging for pre-transplant evaluation using real-time robotic optical coherence tomography,” Communications Engineering,3: 122 (2024). 该工作被Nature Reviews Bioengineering 选为科研亮点 https://doi.org/10.1038/s44222-024-00254-6
代表性科研项目
1.美国 NSF CBET-1254743 “CAREER: Multi-scale Imaging of Neural Interconnects using MRI-compatible Parallel Photonic Needle Interface”02/18/2013 - 02/28/2019；$480,000；主持。
2.美国 NIH R01 DK094877 “Non-Invasive Evaluation of Transplant Kidney using OCT”04/01/2014 - 03/31/2019 ；$1,686,327；参与子课题 $528,960。
3.美国 NIH R03 CA176027 “Monitoring Photo-immunotherapy using Multi-channel Multi-modal Imaging Needles” 10/01/2014 - 9/30/2017；$152,000 ；主持。
4.美国 NIH R01 CA 191207 “Redox Imaging for Breast Cancer Prognosis”07/02/2015 - 6/30/2021；$3,313,520；参与子课题 $297,018。
5.美国 NIH R01EB014946 “Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds”05/10/2015 - 2/29/2020；$1,288,000；主持。
6.美国NIH R01 DK133717 “Automatic Wide-Field Optical Coherence Tomography for Assessment of Transplant Kidney Viability” 09/16/2022 - 07/31/2024；$1,298,263；共同主持。
7.美国NSFCBET-2229356“Pulse Oximetry Measurement Errors Correlated with Patient Skin Pigmentation: Optical Mechanisms and Effect Multipliers”01/01/2023 - 12/31/2024；$200,000；主持。
