个人简介
黄祖芳，教授，光学工程博士生导师。2004年毕业于福建师范大学物理学专业，2013年获得光学工程博士学位，随后2015-2017年在美国约翰霍普金斯大学从事2年的博士后科研工作。近十多年来一直从事生物医学与光学交叉领域的相关研究，早期主要从事光动力诊疗，共聚焦/多光子显微成像研究，目前主要致力于拉曼光谱的检测，拉曼光谱成像以及多元数据方法处理的研究。
承担课程
现代光学成像技术，数字电路实验，模拟电路实验，光信息综合实验以及电工电子学等。
研究方向
主要从事生物医学光学交叉领域的研究，主要开展纳米粒子材料在生物医学诊断的研究应用，生物传感和床旁（Point-of-Care）的医学体外检测（侧重于生殖生育和重大疾病的早期诊断检测）。研究内容涵盖：
1.增强拉曼光谱信号的纳米材料制备与表征；
2.便携式，小型化的生化传感技术、方法的开发；
3. 光谱信号、图像采集，优化以及综合处理分析；
4. 基于光、声镊与微流控技术等，实现细胞、纳米颗粒的微操纵和检测
代表性论文
近年来，在Biosensors and Bioelectronics, Angewandte Chemie, International Journal of Nanomedicine, Analytica Chimica Acta, Talanta, Journal of Biophotonics, Journal of Raman Spectroscopy, Journal of Biomedical Optics, Applied Spectroscopy等国内外主流期刊发表多篇学术论文，发表文章SCI引用1552余次。
部分发表录用论文如下：
Dechan Lu, Yanping Chen, Longfeng Ke, Weilin Wu, Liwen Yuan, Shangyuan Feng, Zufang Huang*, Yudong Lu*, Jing Wang*, Machine learning-assisted global DNA methylation fingerprint analysis for differentiating early-stage lung cancer from benign lung diseases, Biosensors and Bioelectronics, 2023,115235.
Jinyong Lin, Duo Lin, Sufang Qiu, Zufang Huang*, Feng Liu, Wei Huang, Yuanji Xu, Xianzeng Zhang*, Shangyuan Feng*, Shifted-excitation Raman difference spectroscopy for improving in vivo detection of nasopharyngeal carcinoma, Talanta, 2023,257,124330.
Feng Gao, DeChan Lu, TianLei Zheng, shi Geng, JunCheng Sha, OuYang Huang, LiangJie Tang, Peiwu zhu, YangYang Li, LiLi Chen, Giovanni Targher, Christopher D Byrne, ZuFang Huang*, MingHua Zheng*, Fully connected neural network-based serum surface-enhanced Raman spectroscopy accurately identifiesnon-alcoholic steatohepatitis,Hepatol Int, 2022.doi:10.0007/s12072-022-10444-2
Weiming Lin, Shuxia Lai, Dechan Lu, Qun Zhang, Xueliang Lin, Juqiang Lin, Jing Wang*, Zufang Huang*, An acousto-assisted liquid-marble-based microreactor for quantitative SERS detection of alkaline phosphatase, Sensors and Actuators B: Chemical, 2022, 356, 131361.
Dechan Lu, Qun Zhang, Zufang Huang*, Yudong Lu*, Shangyuan Feng*, Ruiyun You, Minling Li, Shaoqin Zhang, Ratiometric SERS quantitative analysis of tyrosinase activity based on gold-gold hybrid nanoparticles with Prussian blue as an internal standard, Colloids and Surfaces B: Biointerfaces, 2022, 217, 112645.
Shengrong Du, Qun Zhang, Haohao Guan, Guannan chen, Sisi Wang, Yan Sun, Yuling Li, Rong Chen, Youwu He, Zufang Huang*，Micro-Raman Analysis of Sperm Cells on Glass Slide: Potential Label-Free Assessment of Sperm DNA toward Clinical Applications, Biosensors: 2022, 12, 1051.
Feng Gao, Dechan Lu, Tianlei Zheng, Shi Geng, Juncheng Sha, Ouyang Huang, Liangjie Tang, Peiwu Zhu, Yangyang Li, Lili Chen, Giovanni Targher, Christopher D.Byrne, Zufang Huang*, Minghua Zheng*, Fully connected neural network-based serum surface-enhanced Raman spectroscopy accurately identifies non-alcoholic steatohepatitis, Hepatology International: 2022, s12072-022-10444-2.
Haohao Guan, Chunyan Huang, Dechan Lu, Guannan Chen, Juqiang Lin, Jianzhang Hu, Youwu He, Zufang Huang*，Label-free Raman spectroscopy: A potential tool for early diagnosis of diabetic keratopathy，Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 256, 119731.
Dechan Lu, Xueliang Lin, Cairou Chen,Yudong Lu*, Shangyuan Feng, Zufang Huang*, Ruiyun You, Jingbo Chen, Yang Wu, Interference-free SERS tags for ultrasensitive quantitative detection of tyrosinase in human serum based on magnetic bead separation, Analytica Chimica Acta, 2020, 1138, 150-157.
Zufang Huang, Soumik Siddhanta, Gang Zheng, Thomas Kickler, and Ishan Barman, Rapid, label-free optical spectroscopy platform for diagnosis of heparin-induced thrombocytopenia, Angewandte Chemie International Edition, 2020, 59, 5972-5978.
Zufang Huang, Shengrong Du, Xiaozhou Liang, Yan Sun, Xiwen Chen, Juqiang Lin, Yongzeng Li, Guannan Chen, Shangyuan Feng, Head-attached live sperm cell for label-free micro-Raman evaluation of sperm DNA integrity: A preliminary study, Journal of Raman Spectroscopy, 2020, 51: 591-595.
Xiaozhou Liang, Xuchao Miao, Weijin Xiao, Qin Ye, Sisi Wang, Juqiang lin, Chao Li, Zufang Huang*, Filter-membrane-based ultrafiltration coupled with surface-enhanced Raman spectroscopy for potential differentiation of benign and malignant thyroid tumors from blood plasma, International Journal of Nanomedicine, 2020, 15: 2303-2314. (通讯作者).
Dechan Lu, Xueliang Lin, Cairou Chen, Yudong Lu*, Shangyuan Feng, Zufang Huang*, Ruiyun You, Jingbo Chen, Yang Wu, Interference-free SERS Tags for ultrasensitive quantitative detection of Tyrosinase in human serum based on magnetic bead separation, Analytica Chimica Acta, 2020（已录用）通讯作者.
Zufang Huang, Arun Nagpal, Soumik Siddhanta, Ishan Barman, Leveraging coffee‐ring effect on plasmonic paper substrate for sensitive analyte detection using Raman spectroscopy, Journal of Raman Spectroscopy, 2018, 49: 1552-1558.
Zufang Huang, Soumik Siddhanta, Chi Zhang, et al., Painting and heating: A nonconventional, scalable route to sensitive biomolecular analysis with plasmon-enhanced spectroscopy, Journal of Raman spectroscopy, 2017, 48: 1365-1374.
Zufang Huang, Gang Cao, Yan Sun, et al., Evaluation and optimization of paper-based SERS substrate for potential label-free Raman analysis of seminal plasma, Journal of nanomaterials, 2017 (Volume 2017, Article ID 4807064).
缪绪超，梁晓周，刘梦梦，林学亮，黄祖芳＊，疏水性SERS基底检测应用研究进展， 激光生物学报，2019, 28: 262-271.
黄祖芳，戈小松，李永增，陈冠楠，冯尚源，林居强，雷晋萍， 基于拉曼光谱技术的甲状腺疾病检测的研究，光谱学与光谱分析，2017，37(11), 3471-3474.
黄祖芳，曹刚，孙艳，杜生荣，李永增，林居强，冯尚源，雷晋萍，陈荣，拉曼光谱技术研究男性生殖生育，光谱学与光谱分析，2016，36(09): 2818-2822.
曹刚，黄祖芳＊，孙艳，杜生荣，林金勇，林居强，冯尚源，雷晋萍，林宏心，陈荣，滤纸SERS基底的制备及其在精浆分析中的应用，光散射学报，2016，28(2): 106-111.(通讯作者)
Zufang Huang, Jing Wang, Rong Chen, et al., Drop coating deposition Raman spectroscopy as a potential tool for identification and determination of fructose in seminal plasma. Journal of Raman spectroscopy, 2014, 45(10): 879-883.
Zufang Huang, Guannan Chen, Rong Chen, et al., Rapid and label-free identification of normalspermatozoa based on image analysis and micro-Raman spectroscopy. Journal of Biophotonics, 2014, 7(9): 671-675.
Jinyong Lin,† Zufang Huang,† Shangyuan Feng, Juqiang Lin,*Nenrong Liu,a Jing Wang, Ling Li, Yongyi Zeng, Buhong Li, Haishan Zengand Rong Chena*, Label-free optical detection of type II diabetesbased on surface-enhanced Raman spectroscopyand multivariate analysis. Journal of Raman spectroscopy, 2014, 45(10): 884-889.(并列第一作者)
Zufang Huang, Xiwen Chen, Rong Chen, et al., Characterization and differentiation ofnormal and abnormal spermatozoa viamicro-Raman spectroscopy. Laser physics letter, 2013, 10: 035601.
Zufang Huang, Xiwen Chen, Rong Chen, et al., Raman spectroscopic characterizationand differentiation of seminal plasma. Journal of biomedical optics, 2011, 16(11):110501.
Xiwen Chen, Zufang Huang＊, Rong chen, et al., Analysis and differentiation of seminal plasma via polarized SERS spectroscopy. International journal of nanomedicine, 2012, 7: 6115-6121. (并列第一作者及通讯作者)
获奖成果
人体组织表面增强拉曼光谱研究，陈荣，林居强，冯尚源，潘建基，黄祖芳，福建省科学技术奖二等奖，2016.6
学术兼职
Journal of Innovative Optical Health Sciences (JIOHS)杂志，青年编委；
福建师范大学学报（自然科学版）青年编委；
中国光学学会第三届生物医学光子学专业委员会委员；
福建省医学会激光医学分会秘书；
福建省口腔医学会第一届口腔激光医学专业委员会常务委员
科研项目
作为项目负责人，获得国家自然科学基金面上2项，国家自然科学基金青年基金1项，福建省自然科学基金重点项目1项，福建省自然科学基金面上项目2项，福建教育厅杰青项目1项等。另外参与了多项国自然面上，国自然国际合作项目等科研项目的合作。
Email：zfhuang@fjnu.edu.cn
