时间：2026年6月10日上午10：00
地点：理工楼18号楼-307学术报告厅
主讲：Lothar Lilge PhD，Princess Margaret Cancer Centre, Toronto Ontario
主办：光电与信息工程学院，医学光电科学与技术教育部重点实验室，福建省光子技术重点实验室
讲座简介
Photodynamic Therapy, gains increasing acceptance in oncology for a range of indications, ranging from basal cell carcinoma to glioma. While surface proximal therapies, such as skin or bladder carcinoma, have high long term cure rates, with the current standardized treatment plans, the success for deep-seated malignancies such as Brain tumours, is limited. Personalized treatment plans based on the tumour size and location have been shown to improve the number of patients with significantly longer-term survivals; however, the fraction of patients not benefiting at all from the intervention remains constant.
While controlling the fluence rate within the confines of the known tissue optical properties has made significant advances, most treatment plans still assume homogenous photosensitizer and oxygen concentrations. We demonstrate that photosensitizer concentration variations on the mm scale can impact treatment planning solutions.
Methods to predict the tissue optical properties, the photosensitizer and oxygen availability, spatially resolved, based on vascular imaging prior to treatment planning and during PDT delivery are discussed. Current treatment plan approaches will be presented.
专家简介
Lothar Lilge obtained the M.Sc. from the Johann Wolfgang Goethe University in Frankfurt, and Ph.D. from the Westfälische Wilhelms University in Muenster. Further training he received at the Wellman Laboratory of Photomedicine at the Mass General Hospital in Boston. At present, he holds faculty appointments at the University of Toronto (Canada) and Johannesburg (South Africa) and is Senior Scientist at the Princess Margaret Cancer Centre, Toronto, Canada.
