李连煌

李连煌

副研究员，硕士生导师

E-mail：lhli@fjnu.edu.cn

多光子显微技术及其应用研究、医学图像分析

Mingwei Zhang, Hailin Lan, Meina Jiang, Minghuan Yang, Hongquan Chen, Shaoli Peng, Xuezhen Wang, Yarui Zhang, Xingxin Huang, Lianhuang Li*, Chun Chen*, Jinsheng Hong*. NLRP3 inflammasome mediates pyroptosis of alveolar macrophages to induce radiation lung injury. Journal of Hazardous Materials, 2025, 484: 136740.

Xiaoxia Li, Qiaojing Lin, Bingyue Guan, Minghuan Yang, Xingxin Huang, Lianhuang Li*, Chun Chen*, Jinsheng Hong*, Mingwei Zhang*. Multi-omics analysis links mitochondrial-related genes to idiopathic pulmonary fibrosis and in vivo transcriptome validation. Translational Research, 2025, 278: 10-21.

Xingxin Huang, Fangmeng Fu, Wenhui Guo, Deyong Kang, Xiahui Han, Liqin Zheng, Zhenlin Zhan, Chuan Wang, Qingyuan Zhang, Shu Wang, Shunwu Xu, Jianli Ma*, Lida Qiu*, Jianxin Chen*, Lianhuang Li*. Prognostic significance of collagen signatures at breast tumor boundary obtained by combining multiphoton imaging and imaging analysis. Cellular Oncology, 2024, 47: 69-80.

Xiong Zhang, Yuan-E Lian, XunBin Yu, Xingxin Huang, Zheng Zhang, Jingyi Zhang, Jianxin Chen, Lianhuang Li*, Yannan Bai*. Label-free characterization of pathological changes in the portal area of liver fibrosis tissue using multiphoton imaging and quantitative image analysis. Journal of Physics D: Applied Physics, 2024, 24: 652.

Lianhuang Li, Shichai Hong, Deyong Kang, Xingxin Huang, Shichao Zhang, Zhenlin Zhan, Yongjian Zhou, Jianxin Chen. Two-photon imaging reveals histopathological changes in gastric tumor microenvironment induced by neoadjuvant treatment. Biomedical Optics Express, 2023, 14: 5085-5096.

Lianhuang Li, Xingxin Huang, Shichao Zhang, Zhenlin Zhan, Deyong Kang, Guoxian Guan, Shuoyu Xu, Yongjian Zhou, Jianxin Chen. Rapid and label-free detection of gastrointestinal stromal tumor via a combination of two-photon microscopy and imaging analysis. BMC Cancer, 2023, 23: 38.

Xingxin Huang, Yuan-E Lian, Lida Qiu, Xunbin Yu, Jikui Miao, Shichao Zhang, Zheng Zhang, Xiong Zhang, Jianxin Chen, Yannan Bai*, Lianhuang Li*. Quantitative assessment of hepatic steatosis using label-free multiphoton imaging and customized image processing program. Laboratory Investigation, 2023, 103: 100223.

Lida Qiu, Deyong Kang, Chuan Wang, Wenhui Guo, Fangmeng Fu, Qingxiang Wu, Gangqin Xi, Jiajia He, Liqin Zheng, Qingyuan Zhang, Xiaoxia Liao, Lianhuang Li*, Jianxin Chen*, Haohua Tu*. Intratumor graph neural network recovers hidden prognostic value of multi-biomarker spatial heterogeneity. Nature Communications, 2022, 13: 4250.

Gangqin Xi, Lida Qiu, Shuoyu Xu, Wenhui Guo, Fangmeng Fu, Deyong Kang, Liqin Zheng, Jiajia He, Qingyuan Zhang, Lianhuang Li*, Chuan Wang*, Jianxin Chen*. Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer. BMC Medicine, 2021, 19: 273.

Gangqin Xi, Wenhui Guo, Deyong Kang, Jianli Ma, Fangmeng Fu, Lida Qiu, Liqin Zheng, Jiajia He, Na Fang, Jianhua Chen, Jingtong Li, Shuangmu Zhuo, Xiaoxia Liao, Haohua Tu, Lianhuang Li*, Qingyuan Zhang*, Chuan Wang*, Stephen A. Boppart*, Jianxin Chen*. Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients. Theranostics, 2021, 11: 3229-3243.

Jiajia He, Fangmeng Fu, Wei Wang, Gangqin Xi, Wenhui Guo, Liqin Zheng, Wenjiao Ren, Lida Qiu, Xingxin Huang, Chuan Wang, Lianhuang Li*, Deyong Kang*, Jianxin Chen*. Prognostic value of tumour-infiltrating lymphocytes based on the evaluation of frequency in patients with oestrogen receptor-positive breast cancer. European Journal of Cancer, 2021, 154: 217-226.

Gangqin Xi, Jiajia He, Deyong Kang, Shuoyu Xu, Wenhui Guo, Fangmeng Fu, Yulan Liu, Liqin Zheng, Lida Qiu, Lianhuang Li*, Chuan Wang*, Jianxin Chen*. Nomogram model combining macro and micro tumor-associated collagen signatures obtained from multiphoton images to predict the histologic grade in breast cancer. Biomedical Optics Express, 2021, 12: 6558-6570.

Lianhuang Li, Zhonghua Han, Lida Qiu, Deyong Kang, Zhenlin Zhan, Haohua Tu, Jianxin Chen. Label-free multiphoton imaging to assess neoadjuvant therapy responses in breast carcinoma. International Journal of Biological Sciences, 2020, 16: 1376-1387.

Lianhuang Li, Deyong Kang, Changyin Feng, Shuangmu Zhuo, Haohua Tu, Yongjian Zhou, Jianxin Chen. Label-free assessment of premalignant gastric lesions using multimodal nonlinear optical microscopy. IEEE Journal of Selected Topics in Quantum Electronics, 2019, 25: 7200806.

科技创新联合资金项目，基于人工智能影像组学联合多光子成像和液体活检技术筛选直肠癌TNT后保器官手术候选者，2024/01-2026/12，合作主持

科技创新联合资金项目，融合多光子显微成像的多模态病理组学智能分析模型在食管癌临床诊疗中的应用，2024/01-2026/12，合作主持

福建省自然科学基金项目，胃癌治疗效果评估的无标记多模式多光子成像研究，2023/08-2026/08，主持

科技创新联合资金项目，基于多光子活检和多组学评估放射性肠纤维化的防治机制，2020/09-2023/09，合作主持

国家自然科学基金面上项目，基于拉曼光谱与多光子显微镜联用系统的肺癌循环肿瘤细胞检测研究，2020/01-2023/12，参与

福建省自然科学基金项目，多光子显微技术用于直肠癌术前放化疗疗效评估的研究，2019/07-2022/06，主持

科技创新联合资金项目，基于非线性光学成像和定量蛋白组学筛选直肠癌新辅助放化疗后保器官策略候选者，2017/12-2020/12，合作主持

国家自然科学基金青年项目，间充质干细胞经后肠系膜动脉灌注联合吡非尼酮治疗大鼠直肠放疗相关纤维化的实验研究，2017/01-2019/12，参与

国家重点基础研究发展计划(973计划)，生物医学信息纳米分辨的光学表征，2015/01-2019/12，参与

国家高技术研究发展计划(863计划)，活体脑多光子显微结构与功能成像关键技术研究，2015/01-2017/12，参与

福建省优秀博士学位论文

福建师范大学优秀毕业研究生

福建省抗癌协会科技进步奖一等奖