林慧韫

林慧韫

副教授，硕士生导师

E-mail：hylin@fjnu.edu.cn

生物和医学光学检测与治疗，智能传感器和检测技术

传感器原理与应用，测量与控制基础实验，开源智能测控技术，光电测量原理与技术等

1.       Huiyun Lin, Yi Shen, Defu Chen, Lisheng Lin, Buhong Li, Shesen Xie, Brian C. Wilson. Feasibility study on quantitative measurement of singlet oxygen generation using singlet oxygen sensor green. Journal of Fluorescence, 2013, 23(1): 41-47

1.       Alisha V. Dsouza, Huiyun Lin, Jason Gunn, Brian W. Pogue，Logarithmic intensity compression in fluorescence guided surgery applications. Journal of Biomedical Optics, 2015, 20(8), 080504

2.       Defu Chen, Ying Wang, Huiyun Lin, Buhong Li, Xuechun Lin, Ying Gu. Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence. Journal of Innovative Optical Health Sciences, 2016, 9(6): 1650019.

3.       Huiyun Lin, Rongxiao Zhang, Jason R Gunn,Tatiana V Esipova, Sergei Vinogradov, David J Gladstone, Lesley A Jarvis, Brian W Pogue, Comparison of Cherenkov excited fluorescence and phosphorescence molecular sensing from tissue with external beam irradiation. Physics in Medicine & Biology, 2016, 61, 3955–3968

4.       Petr Bruza, Huiyun Lin, Sergei A. Vinogradov, Lesley A. Jarvis, David J. Gladstone, Brian W. Pogue, Light sheet luminscence imaging with Cherenkov excitation in thick scattering media. Optics Letters, 2016, 41(13):2986-2989

5.       Alisha V. DSouza, Huiyun Lin, Jonathan T. Elliot, Scott C. Davis, Eric R. Henderson, Kimberley S. Samkoe, Brian W. Pogue, Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging. Journal of Biomedical Optics, 2016, 21(8): 080901-1-080901-15

6.       Buhong Li, Lisheng Lin, Huiyun Lin, Brian C. Wilson, Photosensitized singlet oxygen generation and detection: Recent advances and future perspectives in cancer photodynamic therapy. Journal of Biophotonics, 2016, 9(11-12): 1314-1325

7.       Xianglian Liao, Huiyun Lin*, Buhong Li. Quenching effects of (-)-epigallocatechin-3-gallate for triplet photosensitizer and singlet oxygen during photosensitiza tion. 14th International Conference on Photonics and Imaging in Biology and Medicine (PIBM) © OSA. W3A.130 2017 (大会最佳学生论文奖)

8.       Brian W. Pogue, Jinchao Feng, Ethan P. LaRochelle, Petr Brua, Huiyun Lin, Rongxiao Zhang, Jennifer R. Shell, Hamid Dehghani, Scott C. Davis, Sergei A. Vinogradov, David J. Gladstone & Lesley A. Jarvis. Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging. Nature Biomedical Engineering, 2018, 2:254–264

9.       Lisheng Lin, Huiyun Lin, Yi Shen, Defu Chen, Ying Gu, Brian C. Wilson, Buhong Li. Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy. Photochemistry and Photobiology, 2020, 96:646-651

10.     Xiianglian Liao, Youshi Zheng, Ziguo Lin, Yi Shen, Huiyun Lin, Xiaolong Liu, Da Zhang, Buhong Li. Self-assembled metallo-supramolecular nanoflowers for NIR/acidic-triggered multidrug release, long-term tumor retention and NIR-II fluorescence imaging-guided photo-chemotherapy. Chemical Engineering Journal, 2020, 400:125882

11.     Penghui Shao, Yunpeng Jing, Xiaoguang Duan, Huiyun Lin, Liming Yang, Wei Ren, Fang Deng, Buhong Li, Xubiao Luo, and Shaobin Wang. Revisiting the Graphitized Nanodiamond-Mediated Activation of Peroxymonosulfate: Singlet Oxygenation versus Electron Transfer. Environmental Science and Technology, 2021, 55(23)

12.     Xianglian Liao, Chunxiu Yang, Huiyun Lin, Buhong Li. Quenching effects of (-)-Epigallocatechin gallate for singlet oxygen production and its protection against oxidative damage induced by Ce6-mediated photodynamic therapy in vitro. Photodiagnosis and Photodynamic Therapy, 2021, 36: 102467

13.     Fei Huang, Yu Li, Xingjie Zhang, Meiyu Lin, Guiyan Han, Huiying Lin, Huiyun Lin, Zhenyuan Miao, Buhong Li, Chunquan Sheng, Jianzhong Yao. Novel chlorin e6-based conjugates of tyrosine kinase inhibitors: Synthesis and photobiological evaluation as potent photosensitizers for photodynamic therapy[J]. European Journal of Medicinal Chemistry, 2023, 261: 115787.

14.     Buhong Li, Yi Shen, Huiyun Lin, Brian C. Wilson. Correlation of in vitro cell viability and cumulative singlet oxygen luminescence from protoporphyrin IX in mitochondria and plasma membrane. Photodiagnosis and Photodynamic Therapy, 2024, 46: 104080

15.     Huiyun Lin, Yi Shen, Sizhe Ye, Zufang Huang, Buhong Li. Simultaneous direct and indirect assessments of singlet oxygen generation during vascular-targeted photodynamic therapy with thrombin molecular beacon. Photochemistry and Photobiology, 2025, 101(5):1307-1316.

国家自然科学青年基金项目，基于单线态氧发光检测的EGCG抗光敏氧化效应研究，2016.01-2018.12，20万元，主持

福建省自然科学基金面上项目，动态监测血管靶向光动力效应的荧光-单线态氧成像方法研究，2019/07-2022/06，7万元，主持。

国家自然科学基金重点项目，海姆泊芬的单线态氧增强机制及其定量检测方法，2020/1-2024/12，299万元，参与。

国家自然科学基金重点项目，血管靶向光动力效应的量效关系及其监测技术研究，2011/1-2014/12，96万元，参与

国家自然科学基金国际合作重点研究项目，定量监测光动力血管损伤的多模光学成像技术研究，2016/01-2020/12，250万元，参与。